Acta Mechanica Slovaca 2024, 28(2):68-74 | DOI: 10.21496/ams.2024.019

Three-dimensional Bioprinting with the Use of Induced Pluripotent Stem Cells in Regenerative Medicine

Jana Demeterová*, Marianna Trebuňová, Darina Bačenková
Technical University of Košice, Košice Letná 9 04001, Slovakia

The field of regenerative medicine has witnessed significant advancements in recent years due to the emergence of three-dimensional (3D) bioprinting technology. One promising approach is the utilization of induced pluripotent stem cells (iPSCs) as a cell source for bioprinting, allowing for the construction of complex tissue structures. iPSCs hold immense potential as they can be derived from a patient's own cells, enabling personalized therapies, and eliminating the risk of immune rejection. The integration of iPSCs with 3D bioprinting technology expands the possibilities of regenerating damaged tissues and organs. iPSCs can be programmed to differentiate into various cell types, offering the ability to generate specific tissue structures. The bioprinting process involves the precise deposition of cells, growth factors, and biomaterials in a layer-by-layer manner, mimicking native tissue architecture. This spatial control allows for the creation of intricate tissue constructs with high fidelity, enhancing their integration within the host tissue upon implantation. This review aims to review the current progress and challenges in utilizing 3D bioprinting with iPSCs in regenerative medicine.

Keywords: 3D bioprinting; iPSCs; tissue engineering; regenerative medicine

Received: May 28, 2024; Revised: May 28, 2024; Accepted: July 1, 2024; Published: June 14, 2024  Show citation

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Demeterová, J., Trebuňová, M., & Bačenková, D. (2024). Three-dimensional Bioprinting with the Use of Induced Pluripotent Stem Cells in Regenerative Medicine. Acta Mechanica Slovaca, 28(2), 68-74. doi: 10.21496/ams.2024.019
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