Acta Mechanica Slovaca 2010, 14(2):60-65

Isotope-Selective Infrared Spectroscopy Reveals Pathological Changes in the Liver

Jana Vranová1*, Jozef Rosina2, Jiří Horak, Miluše Hendrichova, Karolina Kratka
1 Department of Medical Biophysics and Medical Informatics, 3rd Faculty of Medicine, Charles University in Prague
2 Faculty of Medicine, Charles University in Prague

An overview of new diagnostic device IRIS (Wagner Analysen Technik, Germany) is provided. This device uses the 13C stable isotope together with non-dispersive infrared selective spectroscopy for non - invasive quantification of hepatic function parameters, including kinetics (type of liver damage) and capacity (percentage of recovery yield of the liver). The short physical principle of infrared spectroscopy and acousto-optical detector of IRIS was presented. In the final section we verified the diagnostic quality of this new diagnostic device (using ANOVA) on cohort of 76 patients divided into 5 groups according to diagnosis and the various level of liver damage.

Keywords: 13C-methacetin, dose, cumulative dose, infrared spectroscopy, transmittance, absorbance, cirrhosis

Published: October 31, 2010  Show citation

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Vranová, J., Rosina, J., Horak, J., Hendrichova, M., & Kratka, K. (2010). Isotope-Selective Infrared Spectroscopy Reveals Pathological Changes in the Liver. Acta Mechanica Slovaca, 14(2), 60-65
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